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Chenrui Wang,Song Cao,Chen Shi,Mengbo Guo,Dongdong Sun,?Zheyi Liu,?Peng Xiu,?Yong Wang,?Guirong Wang?&?Yang Liu.The novel function of an orphan pheromone receptor reveals the sensory specializations of two potential distinct types of sex pheromones in noctuid moth.

文章来源:Cellular and Molecular Life Sciences        点击数: 次      发布时间:2024-06-18

Cellular and Molecular Life Sciences,15 June 2024

Abstract

Sex pheromones play crucial role in mating behavior of moths, involving intricate recognition mechanisms. While insect chemical biology has extensively studied type I pheromones, type II pheromones remain largely unexplored. This study focused on  Helicoverpa armigera , a representative species of noctuid moth, aiming to reassess its sex pheromone composition. Our research unveiled two previously unidentified candidate type II sex pheromones—3Z,6Z,9Z-21:H and 3Z,6Z,9Z-23:H—in  H. armigera . Furthermore, we identified HarmOR11 as an orphan pheromone receptor of 3Z,6Z,9Z-21:H. Through AlphaFold2 structural prediction, molecular docking, and molecular dynamics simulations, we elucidated the structural basis and key residues governing the sensory nuances of both type I and type II pheromone receptors, particularly HarmOR11 and HarmOR13. This study not only reveals the presence and recognition of candidate type II pheromones in a noctuid moth, but also establishes a comprehensive structural framework for PRs, contributing to the understanding of connections between evolutionary adaptations and the emergence of new pheromone types.


Cellular and Molecular Life Sciences,IF=8

https://link.springer.com/article/10.1007/s00018-024-05303-2



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